This page provides direct access to published research, third-party studies, and patent documentation related to activation products featured on this site. The resources below are organized by product to make it easy to review.
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Healthy Glow® (Nrf2 + Collagen)
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Healthy Glow® (Nrf2 + Collagen)
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How Combined Pathways Create Broader System Response
Each activation product is supported by its own body of research and intellectual property. In addition, independent studies and internal validation explore what happens when multiple activation pathways are supported at the same time.
This research focuses on how cellular defense signaling, energy regulation, metabolic communication, and digestive pathways interact as a system rather than as isolated functions. Findings from these studies show that combined pathway activation can produce broader and more adaptive biological responses than individual pathways alone.
For this reason, you'll find stacking and synergy research links within each product section below, where applicable.
Independent Verification
Many of the biological pathways that activation products support are widely studied in the scientific community. For independent verification, explore peer-reviewed publications through PubMed.gov, a public database maintained by the U.S. National Library of Medicine.
Use the suggested search links/terms listed under each product to find published studies related to the same pathways, ingredients, and mechanisms referenced in the research provided on this page.
Example Search:
Searching "Oxidative stress and [topic of interest]" will return published studies examining how oxidative stress is connected to different health concerns.
The Protandim line is built around 3 individual products and the concept of activating the body's own cellular defense and repair systems. Stacking them becomes even more powerful. Below are the links to research and patents.

Lowers Oxidative Stress 40% in 30 days. Increases Glutathione up to 300% in 120 days. Activates cellular resilience & antioxidant enzyme capable of neutralizing more than 1 million free radicals per second.
The NRF2 pathway and oxidative stress response are widely studied in scientific literature. Explore independent, peer-reviewed publications on PubMed.gov. See below for a few examples of how to research.
Research on how Nrf2 regulates cellular defense and antioxidant signaling.
View how widely researched oxidative stress is & learn how detrimental it can be.
Explore how oxidative stress is studied in relation to specific areas of health.
In addition to standalone research, studies and internal validation explore how Nrf2 activation interacts with other cellular and metabolic pathways when used as part of combined product systems, referred to as Stacks. This research examines system-level responses rather than isolated biological functions.

Nrf2 + NRF1
Enhanced Protein Turnover without increased mitochondrial respiration

Nrf2 + NRF1 + NAD+
Multi-pathway activation for multiplied effects

Nrf2 + P84
358 genes activated, improving Cell adaptability and resilience

Nrf2 + TrueScience® Liquid Collagen
Balances Innate Immune Response System

Nrf2 + MindBody
Activates 22 new genes, 9 fatty acid metabolism pathways

Activates Mitochondria Biogenesis, improving Cellular Energy.
The NRF1 pathway and mitochondria are widely studied in scientific literature. Explore independent, peer-reviewed publications on PubMed.gov.
View how widely researched mitochondrial dysfunction is & learn how detrimental it can be
Explore how Mitochondria is studied in relation to specific areas of health

Increases Sirtuin Proteins to activate NAD, improves cell communication.
The NAD pathway and metabolic regulation are widely studied in scientific literature. Explore independent, peer-reviewed publications on PubMed.gov.
Explore how NAD is studied in relation to specific areas of health
In addition to standalone research, studies and internal validation explore how Nrf2, NRF1 and NAD activation interact when used as part of combined product systems, referred to as Stacks.

Nrf2 + NRF1
Enhanced Protein Turnover without increased mitochondrial respiration

Nrf2 + NRF1 + NAD+
Multi-pathway activation for multiplied effects
Supporting digestive health through targeted pathway activation.

Balances Gut Microbiome, improves digestive signaling and Activates Gut Peptides.
The gut microbiome and digestive signaling systems are widely studied in scientific literature. You can explore independent, peer-reviewed publications by searching the terms below on PubMed.gov.
Research on how microbial communities influence digestion, metabolism, and cellular signaling.
Studies examining how the gut lining regulates immune signaling and nutrient communication
Explore how gut microbial balance is studied in relation to specific areas of health
In addition to standalone research, studies and internal validation explore how gut activation interacts with cellular defense and metabolic pathways when used as part of combined product systems, referred to as Stacks.

Nrf2 + P84
358 genes activated, improving Cell adaptability and resilience
Supporting connective tissue integrity and protein signaling.

100% increase in Collagen density and activation of 5 different types of collagen in 8 weeks or less. Activate, Replenish and Maintain Collagen and protein signaling processes that influence connective tissue integrity and cellular response systems
Collagen metabolism and protein signaling pathways are widely studied in scientific literature. You can explore independent, peer-reviewed publications by searching the terms below on PubMed.gov.
Research on how collagen peptides are absorbed, utilized, and distributed within biological systems
Explore how connective tissue and collagen turnover are studied across different biological contexts
Explore how Collagen is studied in relation to specific areas of health
In addition to standalone research, studies and internal validation explore how collagen bioavailability and protein signaling interact with cellular pathways when used as part of combined product systems, referred to as Stacks.

Nrf2 + TrueScience® Liquid Collagen
Balances Innate Immune Response System
Supporting metabolic communication and brain-gut interaction.

Naturally increased GLP-1 by 200% on average. Improves metabolic communication, appetite signaling, and brain-gut interaction.
GLP-1 signaling and metabolic communication pathways are widely studied in scientific literature. You can explore independent, peer-reviewed publications by searching the terms below on PubMed.gov.
Research on how glucagon-like peptide-1 influences appetite, metabolism, and energy regulation
Studies examining how digestive signaling pathways interact with neurological and metabolic systems
Explore how appetite and metabolic signaling are studied across different biological contexts
In addition to standalone research, studies, and internal validation explore how metabolic signaling and appetite regulation interact with cellular pathways when used as part of combined product systems, referred to as Stacks.

Nrf2 + MindBody
Activates 22 new genes, 9 fatty acid metabolism pathways
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