Research & Patents Behind

Activation Technology

This page provides direct access to published research, third-party studies, and patent documentation related to activation products featured on this site. The resources below are organized by product to make it easy to review.

Explore by Product

Protandim® Nrf2

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Protandim® NRF1

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Protandim® NAD+

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TrueScience® Collagen

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P84®

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Healthy Edge® (Nrf2 + P84)

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Protandim Tri-Synergizer

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Healthy Glow® (Nrf2 + Collagen)

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MindBody

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Healthy Weight (Nrf2 + MindBody)

Explore by Product

Protandim® Nrf2

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Protandim® NRF1

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Protandim® NAD+

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TrueScience® Collagen

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P84®

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Healthy Edge® (Nrf2 + P84)

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Protandim Tri-Synergizer

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Healthy Glow® (Nrf2 + Collagen)

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MindBody

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Healthy Weight (Nrf2 + MindBody)

Explore by Product

Stacking Activation Products

How Combined Pathways Create Broader System Response

Each activation product is supported by its own body of research and intellectual property. In addition, independent studies and internal validation explore what happens when multiple activation pathways are supported at the same time.

This research focuses on how cellular defense signaling, energy regulation, metabolic communication, and digestive pathways interact as a system rather than as isolated functions. Findings from these studies show that combined pathway activation can produce broader and more adaptive biological responses than individual pathways alone.

For this reason, you'll find stacking and synergy research links within each product section below, where applicable.

PubMed.gov & Further Research

Independent Verification

Many of the biological pathways that activation products support are widely studied in the scientific community. For independent verification, explore peer-reviewed publications through PubMed.gov, a public database maintained by the U.S. National Library of Medicine.

Use the suggested search links/terms listed under each product to find published studies related to the same pathways, ingredients, and mechanisms referenced in the research provided on this page.

Example Search:

Searching "Oxidative stress and [topic of interest]" will return published studies examining how oxidative stress is connected to different health concerns.

Protandim® - Cellular Activation Product Line

The Protandim line is built around 3 individual products and the concept of activating the body's own cellular defense and repair systems. Stacking them becomes even more powerful. Below are the links to research and patents. 

Protandim® Nrf2

Research & Patents

Lowers Oxidative Stress 40% in 30 days. Increases Glutathione up to 300% in 120 days. Activates cellular resilience & antioxidant enzyme capable of neutralizing more than 1 million free radicals per second.

Explore Related Peer-Reviewed Research (PubMed.gov)

The NRF2 pathway and oxidative stress response are widely studied in scientific literature. Explore independent, peer-reviewed publications on PubMed.gov. See below for a few examples of how to research.

Nrf2 pathway

Research on how Nrf2 regulates cellular defense and antioxidant signaling.

Oxidative stress

View how widely researched oxidative stress is & learn how detrimental it can be.

Oxidative stress and [topic of interest]

Explore how oxidative stress is studied in relation to specific areas of health.

Synergy & Stacking Research

In addition to standalone research, studies and internal validation explore how Nrf2 activation interacts with other cellular and metabolic pathways when used as part of combined product systems, referred to as Stacks. This research examines system-level responses rather than isolated biological functions.

Enhanced Cell Activation

Dual Synergizer Research

Nrf2 + NRF1

Enhanced Protein Turnover without increased mitochondrial respiration

Complete Cell Activation

Tri-Synergizer Research

Nrf2 + NRF1 + NAD+


Multi-pathway activation for multiplied effects

 Gut-CEll ACTIVATION

Healthy Edge Research

Nrf2 + P84

358 genes activated, improving Cell adaptability and resilience

Tissue-Cell ACTIVATION

Healthy Glow Research

Nrf2 + TrueScience® Liquid Collagen


Balances Innate Immune Response System

Metabolic-Cell ACTIVATION

Healthy Weight Research

Nrf2 + MindBody


Activates 22 new genes, 9 fatty acid metabolism pathways

Protandim® NRF1

Activates Mitochondria Biogenesis, improving Cellular Energy.

Explore Related Peer-Reviewed Research (PubMed.gov)

The NRF1 pathway and mitochondria are widely studied in scientific literature. Explore independent, peer-reviewed publications on PubMed.gov.

NRF1 pathway

Research on how NRF1 increases mitochondria biogenesis

Mitochondria dysfunction

View how widely researched mitochondrial dysfunction is & learn how detrimental it can be

Mitochondria and [topic of interest]

Explore how Mitochondria is studied in relation to specific areas of health

Protandim® NAD+

Increases Sirtuin Proteins to activate NAD, improves cell communication.

Explore Related Peer-Reviewed Research (PubMed.gov)

The NAD pathway and metabolic regulation are widely studied in scientific literature. Explore independent, peer-reviewed publications on PubMed.gov.

NAD pathway

Research on how the NAD pathway impacts health

Metabolic regulation

View the importance of metabolic regulation in cells

NAD and (topic of interest)

Explore how NAD is studied in relation to specific areas of health

Synergy & Stacking Research

 In addition to standalone research, studies and internal validation explore how Nrf2, NRF1 and NAD activation interact when used as part of combined product systems, referred to as Stacks.

Enhanced Cell Activation

Dual Synergizer Research

Nrf2 + NRF1

 

Enhanced Protein Turnover without increased mitochondrial respiration

Complete Cell Activation

Tri-Synergizer Research

Nrf2 + NRF1 + NAD+


Multi-pathway activation for multiplied effects

P84® - Gut Health Activation

Supporting digestive health through targeted pathway activation.

P84®

Balances Gut Microbiome, improves digestive signaling and Activates Gut Peptides.

Explore Related Peer-Reviewed Research (PubMed.gov)

The gut microbiome and digestive signaling systems are widely studied in scientific literature. You can explore independent, peer-reviewed publications by searching the terms below on PubMed.gov.

Gut Microbiome

Research on how microbial communities influence digestion, metabolism, and cellular signaling.

Intestinal Barrier Dysfunction

Studies examining how the gut lining regulates immune signaling and nutrient communication

Microbiome and (topic of interest)

Explore how gut microbial balance is studied in relation to specific areas of health

Synergy & Stacking Research

In addition to standalone research, studies and internal validation explore how gut activation interacts with cellular defense and metabolic pathways when used as part of combined product systems, referred to as Stacks.

 Gut-Cell Interaction

Healthy Edge Research

Nrf2 + P84


358 genes activated, improving Cell adaptability and resilience

TrueScience® - Liquid Collagen Activation

Supporting connective tissue integrity and protein signaling.

TrueScience® Liquid Collagen

100% increase in Collagen density and activation of 5 different types of collagen in 8 weeks or less. Activate, Replenish and Maintain Collagen and protein signaling processes that influence connective tissue integrity and cellular response systems

Explore Related Peer-Reviewed Research (PubMed.gov)

Collagen metabolism and protein signaling pathways are widely studied in scientific literature. You can explore independent, peer-reviewed publications by searching the terms below on PubMed.gov.

Collagen Protein

Research on how collagen peptides are absorbed, utilized, and distributed within biological systems

Connective Tissue Metabolism

Explore how connective tissue and collagen turnover are studied across different biological contexts

Collagen and [topic of interest]

Explore how Collagen is studied in relation to specific areas of health

Synergy & Stacking Research

In addition to standalone research, studies and internal validation explore how collagen bioavailability and protein signaling interact with cellular pathways when used as part of combined product systems, referred to as Stacks.

Tissue-Cell ACTIVATION

Healthy Glow Research

Nrf2 + TrueScience® Liquid Collagen

Balances Innate Immune Response System

MindBody® - GLP-1 Activation

Supporting metabolic communication and brain-gut interaction.

MindBody® Activation

Naturally increased GLP-1 by 200% on average. Improves metabolic communication, appetite signaling, and brain-gut interaction.

Explore Related Peer-Reviewed Research (PubMed.gov)

GLP-1 signaling and metabolic communication pathways are widely studied in scientific literature. You can explore independent, peer-reviewed publications by searching the terms below on PubMed.gov.

GLP-1

Research on how glucagon-like peptide-1 influences appetite, metabolism, and energy regulation

Gut Brain Axis

Studies examining how digestive signaling pathways interact with neurological and metabolic systems

GLP-1 and [topic of interest]

Explore how appetite and metabolic signaling are studied across different biological contexts

Synergy & Stacking Research

In addition to standalone research, studies, and internal validation explore how metabolic signaling and appetite regulation interact with cellular pathways when used as part of combined product systems, referred to as Stacks.

Metabolic-Cell ACTIVAtion

Healthy Weight Research

Nrf2 + MindBody

Activates 22 new genes, 9 fatty acid metabolism pathways

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